Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Ø Chemotherapy-induced cognitive impairment (CICI), also known as chemobrain or chemofog, refers to the mental dysfunction experienced by cancer patients/survivors undergoing chemotherapy treatment
Ø The publication emphasizes the importance of understanding the mechanisms underlying CICI to develop effective therapeutic interventions for its alleviation
Ø Animal models play a crucial role in investigating and elucidating the underlying mechanisms of CICI, providing a valuable tool for studying different treatment hypotheses and strategies
Ø The use of animal models in preclinical drug development allows for critical evaluation and validation of potential treatments targeting CICI
Ø The publication also highlights the significance of animal models in advancing our understanding of CICI and facilitating the development of novel therapeutic approaches to mitigate its impact on cancer patients/survivors
Nandakumar, K; Kinra, Manas; Mudgal, Jayesh; Viswanatha, G L.; and John, Jeena, "Animal models of chemotherapy-induced cognitive decline in preclinical drug development" (2021). Health collection. 113.