Wound healing (normal and diabetic) research
Diabetic foot ulcer (DFU) is characterized by a disorder of the inflammatory and proliferative phases of wound healing. Elevated blood glucose retards the wound healing process by increasing proinflammatory cytokines and proteases which reduce growth factor levels, blood flow and cell migration. Impaired angiogenesis, cell proliferation and re-epithelialization are the hallmarks of diabetic wounds. Sesamol (SM), a phyto-constituent obtained from sesame oil, prevents oxidative stress and has hypolipidemic and anti-clastogenic activity. Several studies conducted on SM showed its efficacy in animal models of cognitive decline, diabetes and hyperlipidaemia including wound healing. Our studies state that SM accelerates healing in dexamethasone-induced delayed wound model by increasing inflammatory cells, keratinocyte migration and collagen deposition. Our in vitro data (Karthik et al 2020) in human epidermal keratinocytes suggests that SM increased cell proliferation, migration while regulating expression of Akt, JNK, Notch and MMP-2 in a time-dependent manner. Our in vivo data (unpublished) showed that SM enhanced the rate of wound closure in diabetic foot ulcer model using rats through both oral and topical (in the form of gels) routes. Studies also indicate that sesamol-PLGA nanosuspension significantly promotes acceleration of wound healing in diabetic foot ulcers by restoring altered wound healing process in diabetic conditions
Shenoy, Rekha R., "Wound healing (normal and diabetic) research" (2022). Health collection. 23.