Preparation, characterization, solubility, and bioavailability enhancement of anticancer drugs by cocrystal technology

Document Type

News Article


Therapeutic effectiveness of a drug substance depends upon the bioavailability & ultimately upon the solubility of drug molecules. Solubility is one of the important parameter to achieve desired characterization of drug in systemic circulation for pharmacologic response to be shown. Though there are so many techniques to improve the solubility, cocrystallization is one of the new approaches. These cocrystals include molecular complexes, channel compounds, clathrates.

Cocrystals are discrete neutral molecular reactants which are structurally crystalline materials containing two or more components present in definite stoichiometric amounts. Pharmaceutical cocrystals contain an active pharmaceutical ingredient (API) and a co former which may/may not have pharmacological activity.

Cocrystallization technique can be used as one of the techniques because of its commercial feasibility and also to increase the diversity of solid-state forms of a drug even for non-ionizable drugs, and alter pharmaceutical properties by modification of stability, mechanical behavior, solubility, dissolution rate, and bioavailability. By using the novel approach of generating cocrystals of anticancer drugs with suitable coformers there is an opportunity to improve the solubility and (or) permeability of API resulting in novel dosage forms.

Further Readings:

  1. Designing of Stable Co-crystals of Zoledronic Acid Using Suitable Coformers (jst.go.jp)
  2. applications-of-cocrystals-in-pharmaceutical-drugs.pdf (sysrevpharm.org)
  3. Experimental data of co-crystals of Etravirine and L-tartaric acid - ScienceDirect
  4. Microsoft Word - 32_Vol.15, No.4, 2417-2428, Oct. - Dec., 2022, RJC-6985 (rasayanjournal.co.in)

We look forward for collaborating with researchers with common interest. If interested please contact at krishna.mbs@manipal.edu

Publication Date

Spring 10-30-2022