Alzheimer’s disease and hippocampus Comparison of malondialdehyde levels and superoxide dismutase activity in resveratrol and resveratrol/donepezil combination treatment groups in Alzheimer’s disease induced rat model

Document Type

News Article


Aim: The aim was to determine the malondialdehyde (MDA) level and superoxide dismutase (SOD) activity in Alzheimer’s disease (AD) induced, resveratrol (RS) treated and RS + donepezil (DPZ) treated rat models. The objective was to compare the MDA and SOD levels in all these rat models.

Methods: In the present study, 3 months old male albino Wistar rats, which were in-house bred and weighing 220-250gms were included. The rats were divided into nine subgroups which included control, sham, AD induced, RS treated and DPZ treated groups in different doses and combinations. Lipid peroxidation product in brain homogenate was measured by estimating the levels of thiobarbituric acid reactive substance. Estimation of SOD was done by the method of autoxidation of pyrogallol by Marklund and Marklund.

Results: There was a marked decline in the MDA levels in RS 10 treated group in comparison to AD group (p<0.05). Among the RS 10 and RS 20 groups, RS 10 group showed significantly lower MDA concentration (p<0.05). The SOD activity was higher in the RS 10 and RS 20 treated groups in contrast to the AD group (p<0.05). In, DPZ+RS group, there was a substantial rise in the SOD activity (p<0.05).

Conclusion: In this study, it was witnessed that AD group showed elevated levels of MDA and reduced SOD action. The RS group showed decreased MDA levels and higher SOD action. The RS+DPZ set showed higher SOD activity, in comparison to the RS 10 group. The present study observed that the neuroprotective effect of RS, which may be produced by the reduced oxidative damage in brain tissue in the treated group.

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Publication Date

Spring 10-1-2022