d. Role of resolvins in resolution of periodontal inflammation- Systematic review

Document Type

News Article


  1. Inflammation is a vital defensive process that influences the immune cells, vasculature, and regular functioning of the human system. The purpose of this multifaceted programmed

event is catabasis, i.e. to rid of the primary cause of cellular injury and permit the cells and

tissues to restore homeostasis. In reality, inflammation that is not resolved is recognized as

a driving force of human pathologies, including arthritis, asthma, cancers, and cardiovascular

diseases. Off late, there have been some unrecognized chemical mediators derived from Omega 3 fatty acids, which have been known to enhance the resolution of inflammation. They are the

specialized pro-resolving lipid mediators (SPMs) which include lipoxins (LX), resolvins

(Rv), protectins (PD), and maresins (MaR). Among them, resolvins, have potent immunoregulatory actions. Literature has emerged with variant evidence which demonstrates the effect of resolvins in the restoration of lost periodontal tissues. Hence, this review is a comprehensive compilation of the prevalent literature about resolvins and their role in periodontal disease.

Publication Date

Spring 10-1-2022