Epithelial Reprogramming of HOX Genes by Epigenetic Mechanisms and its implication to Oral Cancers
Whilst genetic alterations in oral cancer have long been documented, epigenetic changes are more recent. Understanding the epigenetic aspects of oral cancer by evaluating DNA methylation status through its various stages of progression and cloning the loci that are methylated at a high frequency shall lead to identifying novel genes that are linked to methylation sites. In this project the goal is to confirm the role of aberrant expression of these HOX genes in oral cancer pathogenesis using robust tissue-engineered equivalents and patient material.
- Kabekkodu SP, Chakrabarty S, Varghese VK, Ghosh S, Radhakrishnan R, Mallya SP, Kudva A. Salivary DNA methylation markers for cancer of oral cavity. Cancer Biomark. 2022 Sep 30. doi: 10.3233/CBM-220028. Epub ahead of print. PMID: 36245370.
Key words” DNA hypermethylation, bisulfite targeted next-generation sequencing, non-invasive marker, oral squamous cell carcinoma, prognosis, saliva
- Basavarajappa DS, Padam KSR, Chakrabarty S, An NK, Radhakrishnan R. The regulatory role of HOX interacting lncRNA in oral cancer-An in silico analysis. J Oral Pathol Med. 2022 Sep;51(8):684-693. doi: 10.1111/jop.13329. Epub 2022 Aug 7. PMID: 35766359.
Keywords: HOX, HOX-interacting long noncoding RNAs, long noncoding RNA, oral cancer.
- Shenoy US, Adiga D, Kabekkodu SP, Hunter KD, Radhakrishnan R. Molecular implications of HOX genes targeting multiple signaling pathways in cancer. Cell Biol Toxicol. 2022 Feb;38(1):1-30. doi: 10.1007/s10565-021-09657-2. Epub 2021 Oct 6. PMID: 34617205; PMCID: PMC8789642.
All publications: https://pubmed.ncbi.nlm.nih.gov/?term=raghu%20radhakrishnan&sort=date
1. Title: Epithelial Reprograming of HOX Genes by Epigenetic Mechanisms and its implication to Oral Cancers.
PI: Raghu Radhakrishnan
Duration: 01/09/19 - 01/08/24
Radhakrishnan, Raghu, "Epithelial Reprogramming of HOX Genes by Epigenetic Mechanisms and its implication to Oral Cancers" (2022). Health collection. 55.