Date of Award
Dr. Girish Thunga
Dr. Ravindra Munoli
Abstract: Background: Prompt recognition and optimal management of hyponatremia will help the physician devise a better treatment plan to prevent future complications. Hence this study aims to identify of risk factors associated with hyponatremia in psychiatric patients.Methods: A case-control study was conducted among psychiatric inpatients in a tertiary care teaching hospital. Patients admitted from January 2013 to December 2017 were identified using ICD-10 code F01-F99. Patients with serum sodium levels <135 mmol/L were considered as hyponatremia and between 135-145 mmol/L as controls. Factors associated with causing hyponatremia were identified by multiple logistic regression and odds ratio (OR) was calculated.Results: Based on the inclusion and exclusion criteria, 264 cases of hyponatremia and 253 matching controls were included in the study. The mean age of patients with hyponatremia was 56.4±16.8 years as compared to 39.6±13.9 years in controls and 65.7% of them were males. Seizure disorder (OR=3.14, olar disorder (OR=6.03, p=0.001), depression (OR=4.78, p=0.005) and use of quetiapine (OR=2.11, p =0.007), insulin (OR=3.53, p=0.038) were independent risk factors associated with development of hyponatremia. Conclusion: Psychiatric patients with seizure disorder, bipolar disorder, depression and using quetiapine or insulin have more chance of developing hyponatremia. And they should be monitored carefully.
Kunhikatta, Vijaynarayana, "Identification of risk factors for hyponatremia in psychiatric patients undergoing treatment: A case control study." (2019). Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations. 33.