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Manipal Journal of Nursing and Health Sciences

Designation

Professor.

Abstract

Background: Organophosphorus (OP) poisoning is a significant public health problem globally, leading to symptoms such as cholinergic crisis, intermediate syndrome, and altered consciousness. Proper administration of atropine, based on acetylcholinesterase enzyme levels, is critical to prevent deterioration. This study aims to describe how atropine titration parameters affect clinical outcomes in patients with organophosphorus poisoning

Materials and Methods: An observational cohort study included 46 OP poisoning patients aged over 18 years, admitted to the Intensive Care Unit (ICU). Data were collected within 24 hours of ICU admission using structured checklists covering demographic profiles, atropine titration, and clinical outcomes. Descriptive statistics were used to analyze the data, presented as frequencies and percentages. Results: Out of 46 patients, 35 (76.1%) recovered. Ventilator support was required for less than 5 days in 32 (69.5%) patients, and 16 (34.8%) patients were treated in the ICU for less than 5 days. Additionally, 32 (69.6%) were managed in the High Dependency Unit (HDU). Conclusion: This study demonstrates that judicious and individualized titration of atropine plays a crucial role in improving clinical outcomes among patients with organophosphorus poisoning. Timely adjustment of atropine dosing based on clinical parameters and acetylcholinesterase levels was associated with higher recovery rates, reduced duration of ventilator support, shorter ICU stay, and earlier transition to high-dependency care.

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