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Manipal Journal of Pharmaceutical Sciences

Abstract

The objective of this work was to develop temperature triggered in situ ophthalmic gel of moxifloxacin using Pluronic F-127 as a gelling agent to improve duration of contact with cornea. These systems are used as eye drops as they undergo reversible phase transformation within the cul-de-sac and thereby increase the ocular bioavailability and reduce the administration frequency. In the present study, moxifloxacin (a fluoroquinolone antibiotic) was used as a model drug. The work was planned to formulate ophthalmic in situ gel using Pluronic F-127 a gelling agent with hydroxyl propyl methyl cellulose K4M as viscosity imparting agent, sodium chloride as a tonicity modifier and benzalkonium chloride as a preservative. All the formulations were evaluated for appearance, pH, drug content uniformity, in vitro gelation studies, rheological studies, test for sterility, in vitro release studies and stability studies. Formulation PF2 was chosen as best formulation on the basis of its capacity to prolong the drug release till 8 hours. Percent drug content was 96.94±0.583%. The viscosity before gelation was 15.0±2.80 cps and after gelation was 683.3±15.2 cps at 20 rpm. The drug release was 78.65±1.71% after 8 hours for PF2 formulation.

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