Manipal Journal of Pharmaceutical Sciences


Antibiotic resistance is one of the leading medical crises in the world today. The antibiotic resistant strains are presenting a serious threat to the health of individuals. The strains of Staphylococcus aureus, which are untreatable by any existing antibiotics, were developed already. According to World Health Organization, 4,80,000 people develop drug resistant tuberculosis each year, globally. Ever since the antibiotics were discovered, the resistant strains have been challenging the efficacy of the developed antibiotics. This crisis has been due to the lack of new drugs and due to the misuse of the existing antibiotics. This review presents the emergence, molecular mechanisms of developing resistance, and strategies for minimizing the resistance.