In vitro cytocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional crosslinking comonomer

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World Journal of Dentistry


Aim and objective: The present research aimed to assess the cytocompatibility of a novel dental restorative composite resin (DRC) copolymer containing dipentaerythritol penta-/hexa-acrylate (DPEPHA) as comonomer by tetrazolium assay. Materials and methods: Twenty-seven photopolymerized specimens (n = 9 per group) were divided into a control G0 group (specimens without DPEPHA) and two trial groups [specimens with 20 wt% (G20) and 40 wt% (G40) DPEPHA]. Eluates from the specimens were extracted and filtered. L929 mouse fibroblasts were employed and an MTT assay was executed. Parametric tests and multiple comparison tests were utilized to analogize the average optical density (OD) and fibroblastic viability among and between the study groups, respectively. Results: A significant difference was apparent (p = 0.000) when the means of OD and cell viability of the groups were compared. The assessed parameters were higher for the trial groups than the control. The novel copolymer P(GEU-Co-DPEPHA) (trial groups) possessed higher OD and fibroblastic viability than the P(GEU) (control). Conclusion: The novel copolymer P(GEU-Co-DPEPHA) formed by the addition of DPEPHA in propriety DRC matrix was cytocompatible with L929 fibroblasts. Clinical significance: P(GEU-Co-DPEPHA) is cytocompatible with the mammalian fibroblasts. Hence, the substitution of this crosslinking comonomer would improvise the physicomechanical properties of the DRCs without compromising biocompatibility.

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