Malignant Melanoma of Nose and Paranasal Sinuses: a Case Series

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Indian Journal of Otolaryngology and Head and Neck Surgery


Malignant melanoma of nose and paranasal sinus is a rare and devastating disease. The incidence of intranasal malignant melanomas varies from 0.6 to 3.8%. Extensive local invasion, tumor recurrence, distant metastasis accounts for the poor prognosis with advanced stage having mean survival time of 3.5 years. Here we report 2 cases of malignant melanoma of the left nasal cavity with extensive local invasion to paranasal sinuses and destroying medial orbital wall in both cases along with one eroding cribriform plate and extending intracranially. Both the patient presented with almost similar complaints of unilateral nasal obstruction progressing to bilateral with intermittent episodes of epistaxis and unilateral epiphora. Biopsy from the lesion was proved out to be Malignant melanoma in both the cases. All preliminary radiological investigations including metastatic workup was done. Though there was no evidence of distant metastasis in both the cases, because of extensive local destruction and patient’s preference, both opted for non-surgical management



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