Insulin resistance and the severity of coronary artery disease based on obesity status in stable-angina patients: A cross-sectional analysis

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Journal of Applied Pharmaceutical Science


The evaluation of coronary artery disease (CAD) concerning the metabolic status and body mass index (BMI) is poorly studied. This study was designed to observe the relationship between insulin resistance (IR) and the severity of CAD on the basis of the metabolic and phenotypic status in stable-angina patients. A cross-sectional study was conducted on 532 patients with stable angina and coronary angiogram was done to diagnose the CAD for all. Determination of metabolic obesity was done using the National Cholesterol Education Program-Adult Treatment Panel III criteria. Phenotypic obesity was defined as BMI ≥ 25 kg/m . Homeostasis model assessment IR in correlation with the severity of CAD was measured using SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries) Score. The average age of the patients was 57.58 ± 10.40 years, and 69.4% were males. Out of 532 subjects, 51.3% were hypertensive, 14.5% were smokers, 29.1% consumed alcohol, 49.3% were metabolically obese, and 50% were phenotypically obese. Increase in IR increased the risk of severity of CAD in metabolically obese subjects (OR = 2.51, p = 0.048). In the phenotypically obese group, the relationship between IR and the severity of CAD was not statistically significant (OR = -2.19, p = 0.08). The study concludes that the increased IR increases the risk of severity of CAD in metabolically obese subjects. 2

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