Impact of nutrient-gene-interaction on periodontal diseasesan over view

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Indian Journal of Forensic Medicine and Toxicology


The key role to maintain equilibrium between microbial challenge and host response is played by nutrition, which is also important in various chronic diseases like cardiovascular disease, type 2 diabetes & rheumatoid arthritis. An individual’s baseline inflammatory position is influenced by macronutrients & micronutrients which modulate pro inflammatory and anti-inflammatory cascades. The aim of this review is to give an insight on mechanism of action of various macronutrients, micronutrients and some of the trace elements with their positive effects in resolution of various chronic diseases such as diabetes, cardiovascular, cancer and periodontal diseases. Thus dietary changes can be associated with genetic composition, this in turn may be due to changes in individual response. This highlights the significance of unravelling the role of nutrient gene interaction in progression of chronic diseases. Periodontitis is linked to a number of chronic systemic diseases which emphasize the significance of effective periodontal disease management for tooth retention as well as for overall health.

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