Water Detoxification, Drug Designing, and developing laser-induced novel crystallization techniques
Document Type
News Article
Abstract
Structural biology is an interdisciplinary area requiring expertise from the life and physical sciences. In our lab, we use single-crystal X-ray crystallography to determine the atomic structure of proteins and small molecules. In addition, we use molecular biology, biochemical and biophysical approaches to understand protein-ligand interactions. Molecular docking, molecular dynamics, and bioinformatics tools are employed to understand the fundamental aspects of protein structure, stability, folding, and function. The research focus includes (1) Investigating the mechanism of transport and detoxification of heavy metals and metalloids in bacteria, mammals, and plants. (2) Elucidating the enzymes of the arsenic biomethylation. (3) Identification of indigenous plants to remove heavy metals in industry-contaminated water. (4) Investigation of structures of proteins and their complexes with other proteins, nucleic acids, and ligands and development of drug molecules for cancer, Influenza, HIV, etc. (5) Development of novel crystallization techniques using lasers and identification of biomaterials (nucleants) for proteins and small molecules (drug molecules) crystallization. (6) Applied nanoscience and laser spectroscopic techniques for biological and environmental applications. (7) Spectroscopic studies of protein and ligand molecules.
Recent Publications:
- https://doi.org/10.1016/j.compbiolchem.2022.107776
- https://doi.org/10.1016/j.bioorg.2022.106170
- https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA02245H
Publication Date
Spring 10-1-2022
Recommended Citation
Abdul Salam, Abdul Ajees, "Water Detoxification, Drug Designing, and developing laser-induced novel crystallization techniques" (2022). Basic Science Collection. 18.
https://impressions.manipal.edu/basic-science-collection/18
