Date of Award
Winter 1-4-2019
Document Type
Dissertation
Degree Name
MPharm Pharmacy Practice
Department
Department of Pharmacy Practice
First Advisor
Dr Muralidhar verma
Abstract
Intoduction: The risk of cardiovascular diseases in people living with HIV is greater than in normal individuals Objectives: 1. To Assess the cardiovascular risks in people living with HIV with HAART using standard cardiovascular risk scores. 2. To compare the pattern of cardiovascular disease risk associated with HIV seropositive patients with HAART. Methodology: Patients diagnosed with HIV with HAART with one or other cardiovascular diseases will be enrolled. The data related to various cardiovascular diseases, the duration of cardiovascular disease with onset of HIV infection with HAART. The enrolled patients will be evaluated by using various validated cardiovascular risk scores like the Framingham risk score, American College of Cardiology/American heart association (ACC/AHA) risk score, the Second manifestations of arterial disease (SMART) risk scores. The outcome of the result scores will be compared between the various scores and risk will be categorized. The pattern of cardiovascular risk with its incidence will be reported. RESULTS: When the results of the Framingham score was compared with that of the AHA score the kappa coefficient value obtained was 0.282 which shows a fair agreement (0.21 – 0.40) between these two scores. In a similar way, the results of SMART score was compared with that of AHA score, the kappa coefficient value was 0.597 which shows a moderate agreement (0.41 – 0.60) between the scores. And when the results of the Framingham score were compared with SMART score the kappa coefficient value was 0.250 which shows a fair agreement (0.21 – 0.40) between the scores.onclusion: ACC/AHA score is the most commonly used score for cv risk scoring India, and when it was compared with Framingham and SMART score showed fair to moderate agreement concluding that these scores can also be used in addition to AHA score for calculating cv risk
Recommended Citation
Radhakrishnan, Rajesh Dr, "Comparison of various Cardiovascular risk scores to assess cardiovascular risk in people living with HIV on HAART in Kasturba Hospital Manipal" (2019). Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations. 7.
https://impressions.manipal.edu/mcops/7
