Significance of Serum Uric Acid levels in non-arthritic Psoriasis with special reference to Metabolic Syndrome

Authors

Chetana Shenoy, Junior Research Fellow & PhD scholar, Department of Dermatology, Yenepoya Medical college, Yenepoya University, Deralakatte, Mangalore – 575018.Follow
Manjunath Shenoy M, Department of Dermatology, Yenepoya medical college, Yenepoya University, Deralakatte, Mangalore -575018Follow
Manjula Shantaram, Coordinator, Department. of post graduate Studies & Research in Biochemistry, Department of PG Studies and Research in Biochemistry, PG Center, Chikka Aluvara 571232, Kodagu. Professor, Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore-575 018.Follow
Soumya Shetty, Biostatistician, Department of Community Medicine, Yenepoya Medical college, Yenepoya University, Deralakatte, Mangalore – 575018.Follow
Nitin B. Nair, Junior resident, Department of Dermatology, Yenepoya Medical college, Yenepoya University, Deralakatte, Mangalore – 575018.Follow
Arjun Ajay Shankar, Junior resident, Department of Dermatology, Yenepoya Medical college, Yenepoya University, Deralakatte, Mangalore – 575018.Follow

Abstract

Background: Psoriasis has been considered of late as dermatological disorder with systemic inflammation that could contribute to various systemic events. There are studies that have demonstrated increased Serum uric acid levels in patients with psoriasis and psoriatic arthritis. There have been no studies so far on Uric acid levels in relation to psoriasis and metabolic syndrome (MetS). Objectives: The purpose of this study was to investigate the possible presence of hyperuricemia in non-arthritic psoriasis and to analyze serum uric acid levels in psoriasis patients with and without MetS and in controls with and without MetS. Uric acid levels were also correlated with severity and duration of psoriasis. Materials and Methods: We performed a case control study on 100 psoriasis patients, 39 with MetS and 61 without MetS and 100 controls, 22 with and 78 without MetS, matched for age and sex. Serum uric acid levels were measured in all groups. Results: The overall serum uric acid levels were significantly higher in psoriasis patients when compared to the controls (P = 0.001). A significant increase was also observed in psoriasis patients with MetS than those without MetS in the same group (P =

Recommended Citation

Shenoy, Chetana; Shenoy M, Manjunath; Shantaram, Manjula; Shetty, Soumya; Nair, Nitin B.; and Shankar, Arjun Ajay (2016) "Significance of Serum Uric Acid levels in non-arthritic Psoriasis with special reference to Metabolic Syndrome," Manipal Journal of Medical Sciences: Vol. 1: Iss. 1, Article 3.
Available at: https://impressions.manipal.edu/mjms/vol1/iss1/3