Manipal Journal of Medical Sciences


Promethazine is a first generation antihistaminic belonging to phenothiazine family. Because of its strong anticholinergic property, it is used for the treatment of drug-induced dystonia, which is characterized by sustained or repetitive involuntary muscle contractions associated with twisting or repetitive movements with abnormal postures. Promethazine, which is used to treat dystonia, can itself rarely cause dystonia as an adverse effect. Here, we present a rare case of promethazine induced acute dystonia