Manipal Journal of Medical Sciences


Objective: 1) To evaluate the anti-inflammatory (AI) potential of hyoscine 2) To compare it with indomethacin in acute/sub-acute animal model Method/Methodology: Fully grown albinowistar rats which weighed 150-200 grams were divided into three groups of six animals each. The control, standard, and test constituted different groups and had received normal saline 5ml/kg of body weight, indomethacin 10 mg/kg of body weight and hyoscine 9 mg/kg of body weight, respectively. Acute/sub-acute AI activity was assessed through Carrageenan Induced Paw Oedema (CIRPEM), and Cotton Pellet Induced Granuloma Model (CPIGM), respectively. Results: In CIRPEM, the percentage of inhibition of the paw oedema, which signifies anti-inflammatory activity, by indomethacin and hyoscine with regard to control were 50.5% and 30.8% and the test group was 61% of the standard group. Whereas in CPIGM, the percentage of the inhibition of granuloma formation with regard to control by standard and test were 48.7% and 39.1%, respectively, and the test group was 80.3% of standard/ indomethacin group.Conclusion: Hyoscine showed considerably good AI in acute/ sub-acute AI models