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Manipal Journal of Medical Sciences

Abstract

Background: As of today, no standard treatment protocol nor preventive measures either exists for oral lichen planus. The present investigation aimed to test topical 0.1% tacrolimus as compared to Colgate Oraguard-B paste for managing lesions of oral lichen planus. Methods: It was a hospital-based prospective study with histopathologically confirmed 135 patients of oral lichen planus as subjects, which were provided with 0.1% tacrolimus ointment with Colgate Oraguard-B paste. The duration of treatment ranged from three to four months, with a follow-up of till two years. Study subjects were followed up every fifteen days. The results were expressed using mean and standard deviation. Wilcoxon signed-rank test was used to test the significance. Results: At the time of the first visit, pain intensity was the worst (visual analogue scale (VAS) scores 9-10). Scores came down to 1-2 (significant reduction in pain) after two months of therapy. Mean values of pre and post VAS scores in the domain of erosive type of oral lichen planus were 9.47±1.22 and 2.84±0.27. Differences in pre and post VAS scores were found to be significant for oral lichen planus. Conclusions: Subjects reported a significant decrease in pain by the intervention (topical 0.1% tacrolimus ointment with Oraguard-B past) in a short period. This provided us with a new line of management with promising results for managing oral lichen planus.

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