Manipal Journal of Medical Sciences


Introduction: This retrospective study analyses the demographics, clinical features, and comorbidities of patients admitted with COVID-19. The study also evaluates the association of two biomarkers namely D-dimer and CRP (C-reactive protein) with the severity of the infection. Methods: Data of COVID-19 patients admitted from 1 June 2020 to 31 August 2020 was collected based on age, sex, date of admission and discharge, the severity of infection, final disposition, treatment, biomarkers (C-reactive protein and D-dimer), other associated presentations, and comorbidities through a chart review. The severity of infection was categorized into asymptomatic, mild, moderate, or severe, based on WHO criteria. Results: A total of 337 patients were included in the study. There were 219 (64.99%) male and 118 (35.01%) female patients. The most common age group overall was 40-45 years. In the severe category of patients, the most common age group was 80-85 years of age. The average age among patients who died from COVID-19 was 65.89 years. Around 22 patients (6.53%) were asymptomatic, 231 patients (68.55%) were mild, 11 patients (3.26%) were moderate, and 73 patients (21.66%) were severe. There were nine deaths (2.67%). Diabetes mellitus (DM) was present in 114 (38.13%) adult symptomatic patients. Hypertension was present in 100 (33.44%) adult symptomatic patients. Differences in median CRP and D-dimer values were statistically significant between the mild and moderate to severe COVID-19 patients. Conclusion: This study highlights the important demographics and comorbidities in COVID-19 and their relationship to the severity of illness. The study also evaluates two biomarkers, CRP and D-dimer in differentiating mild and moderate to severe cases.