Cathodal Transcranial Direct Current Stimulation (c-tDCS) Primed Intermittent Theta Burst Stimulation (iTBS) over Left Dorsolateral Prefrontal Cortex for Depression: A Case Report

Authors

Ashok Jammigumpula, Kasturba Medical College, ManipalFollow
PN Abhiram, Kasturba Medical College, ManipalFollow
Vidyashree MS, Kasturba Medical College, ManipalFollow
Abhishikta S. Naik, Kasturba Medical College, ManipalFollow
Sonia Shenoy, Kasturba Medical College, ManipalFollow
Samir Kumar Praharaj Dr, Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Udupi district, Karnataka, IndiaFollow

Abstract

Newer treatment modalities such as non-invasive brain stimulation techniques including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are being studied for the treatment of depression. In this paper a patient is reported with treatment-resistant depression who responded to treatment with a novel cathodal tDCS primed intermittent theta burst stimulation (iTBS) protocol targeted at the left dorsolateral prefrontal cortex administered over five consecutive days. Possibly, the inhibitory effect of cathodal-tDCS facilitates the excitatory effects of iTBS by homeostatic metaplasticity and improves efficacy by reducing the inter-hemispheric imbalance in prefrontal cortex activity.

Recommended Citation

Jammigumpula, Ashok; Abhiram, PN; MS, Vidyashree; Naik, Abhishikta S.; Shenoy, Sonia; and Praharaj, Samir Kumar Dr (2022) "Cathodal Transcranial Direct Current Stimulation (c-tDCS) Primed Intermittent Theta Burst Stimulation (iTBS) over Left Dorsolateral Prefrontal Cortex for Depression: A Case Report," Manipal Journal of Medical Sciences: Vol. 7: Iss. 1, Article 3.
Available at: https://impressions.manipal.edu/mjms/vol7/iss1/3