Newer treatment modalities such as non-invasive brain stimulation techniques including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are being studied for the treatment of depression. In this paper a patient is reported with treatment-resistant depression who responded to treatment with a novel cathodal tDCS primed intermittent theta burst stimulation (iTBS) protocol targeted at the left dorsolateral prefrontal cortex administered over five consecutive days. Possibly, the inhibitory effect of cathodal-tDCS facilitates the excitatory effects of iTBS by homeostatic metaplasticity and improves efficacy by reducing the inter-hemispheric imbalance in prefrontal cortex activity.
Jammigumpula, Ashok; Abhiram, PN; MS, Vidyashree; Naik, Abhishikta S.; Shenoy, Sonia; and Praharaj, Samir Kumar Dr
"Cathodal Transcranial Direct Current Stimulation (c-tDCS) Primed Intermittent Theta Burst Stimulation (iTBS) over Left Dorsolateral Prefrontal Cortex for Depression: A Case Report,"
Manipal Journal of Medical Sciences: Vol. 7:
1, Article 3.
Available at: https://impressions.manipal.edu/mjms/vol7/iss1/3