Manipal Journal of Science and Technology
Abstract
Wound healing is a crucial process that underlines the body’s ability to recover and restore damaged tissues. Conventional cotton-based dressings act as a physical barrier between the environment and open wound and are not actively involved in wound healing. This type of dressing can lead to maceration of scab, and infection and can cause pain upon removal. Functionalized nanofibre patches that can accelerate wound healing are being researched worldwide to overcome these challenges. Electrospinning has emerged as the most promising technique for engineering nanofibres for diverse applications. In this study, the wound-healing potential of PVA nanofibres functionalized with different concentrations (0.1%, 0.2%, 0.3%, 0.5%, and 1 wt%) of Moringa oleifera (MO) extracts are explored. This study provides insights into the influence of different parameters such as polymeric solution concentration, needle size, tip-to-collector distance, the high voltage applied, and types of collectors on nanofibre production. These parameters are optimized to produce nanofibre patches using a self-assembled indigenous electrospinning setup. The produced nanofibres were characterized and the average diameter of unloaded and loaded PVA nanofibres was found to be ~125 nm and ~450 nm respectively.
Recommended Citation
Ghosh, Suvarna; Sudha, Merla; R S, Rakshith Prajwal; Nadaf, Sameer A; R S, Shreya; Biswas, Pronama; and Desai, Belaguppa Manjunath Ashwin
(2024)
"Development of Poly-vinyl alcohol (PVA) and Moringa oleifera-based nanofibre patches for wound healing using an indigenous electrospinning setup,"
Manipal Journal of Science and Technology: Vol. 9:
Iss.
1, Article 6.
Available at:
https://impressions.manipal.edu/mjst/vol9/iss1/6