Date of Award
5-2019
Document Type
Thesis
Degree Name
B.Sc. Biotechnology
Department
Department of Biotechnology
First Advisor
Dr. Nirmal Mazumder
Second Advisor
Dr. K K Mahato
Abstract
Most of the diseases in remote rural areas as well as in developing countries are detected late at some advanced stages and, hence causing higher fatalities. Therefore, early detection and diagnosis of diseases is a key area of research for controlling disease progression. The main problem being targeted in this study is the delay of disease detection in remote rural areas and developing countries. A new age optical microscope for low cost, high sensitivity diagnosis is essential, particularly in remote areas around the world could revolutionize the process of disease diagnosis. The portable optical microscope using optics and smartphone interface with an attached lens is developed to bridge the gap in diagnosis. The device was built using acrylic sheets to make it less bulky & customizable and 3D printed mechanical parts to increase stability. The study included fabrication of the device, testing with diseased samples along with controls to determine its diagnostic capability. Images were acquired using the Ultra-BLIPS lens integrated to smartphones and were compared with a traditional optical microscope. It was observed that the images from the smartphone were comparable. We achieved single cell resolution using the developed device. To further increase the efficiency of the proposed smartphone-based microscope, deep learning-based image analysis can be integrated.
Recommended Citation
Banik, Soumyabrata, "Development of a cost-effective, portable and easy-to-use device for disease detection" (2019). Manipal School of Life Sciences, Manipal Theses and Dissertations. 6.
https://impressions.manipal.edu/mlsc/6
