Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Authors

Vasanth Kumar Mamadapur, Kasturba Medical College, Manipal
Shreesha Nagaraju, Kasturba Medical College, Manipal
Mukhyaprana M. Prabhu, Kasturba Medical College, Manipal

Document Type

Article

Publication Title

Medicina (Lithuania)

Abstract

Background and Objectives: Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis, a member of the Mycobacterium tuberculosis complex. It contributes to significant morbidity and mortality. Treatment of TB poses a considerable challenge because of emerging drug resistance and the longer duration of therapy. Various past studies, both in vitro and in vivo, have established the role of vitamin D in the pathogenesis and treatment of TB. Results of in vivo studies are inconsistent, and this study aims to determine vitamin D levels and their association with newly diagnosed TB (pulmonary and extrapulmonary) cases and normal populations. Material and Methods: A Prospective Case-Control study with 116 subjects (58 cases and 58 controls) was conducted over two years. 29 cases of pulmonary TB and 29 cases of extrapulmonary TB constituted 58 cases of TB. Vitamin D levels were measured and compared in both the cases and controls. Data analysis was carried out using SPSS software 22.0. Results: The prevalence of vitamin D deficiency was 68.96% in the cases, while it was 51.72% in the controls. The reported median and quartile of serum vitamin D levels were 14.35 ng/mL (8.65, 25.48) in the TB group and 19.08 ng/mL (13.92, 26.17) in the control group. There was a significant statistical difference between the TB and non-TB populations with a p-value of 0.029 on the Mann–Whitney test. Conclusion: Vitamin D deficiency was more prevalent in individuals with TB than those without TB.

DOI

10.3390/medicina60050685

Publication Date

5-1-2024

Recommended Citation

Mamadapur, Vasanth Kumar; Nagaraju, Shreesha; and Prabhu, Mukhyaprana M., "Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population" (2024). Open Access archive. 10431.
https://impressions.manipal.edu/open-access-archive/10431