Pseudomonas aeruginosa: metabolic allies and adversaries in the world of polymicrobial infections
Document Type
Article
Publication Title
Critical Reviews in Microbiology
Abstract
Pseudomonas aeruginosa (PA), an opportunistic human pathogen that is frequently linked with chronic infections in immunocompromised individuals, is also metabolically versatile, and thrives in diverse environments. Additionally, studies report that PA can interact with other microorganisms, such as bacteria, and fungi, producing unique metabolites that can modulate the host immune response, and contribute to disease pathogenesis. This review summarizes the current knowledge related to the metabolic interactions of PA with other microorganisms (Staphylococcus, Acinetobacter, Klebsiella, Enterococcus, and Candida) and human hosts, and the importance of these interactions in a polymicrobial context. Further, we highlight the potential applications of studying these metabolic interactions toward designing better diagnostic tools, and therapeutic strategies to prevent, and treat infections caused by this pathogen.
DOI
10.1080/1040841X.2024.2397359
Publication Date
1-1-2024
Recommended Citation
Sachdeva, Chandni; Satyamoorthy, Kapaettu; and Murali, Thokur Sreepathy, "Pseudomonas aeruginosa: metabolic allies and adversaries in the world of polymicrobial infections" (2024). Open Access archive. 10754.
https://impressions.manipal.edu/open-access-archive/10754
