Selecting an Appropriate Animal Model for Dyslipidemia
Document Type
Article
Publication Title
Indian Journal of Pharmaceutical Education and Research
Abstract
In recent years, dyslipidemia, a major risk factor for cardiovascular diseases is on the rise globally due to sedentary lifestyles and unhealthy diets. Though abundant data pertaining to the factors influencing dyslipidemia, the mechanism of action of various drugs and the pathogenesis of the disease are available in the literature, the disease is poorly understood. Animal models play a crucial role in investigating the pathophysiology and aid in developing effective formulations. Despite extensive research being carried out in the arena of dyslipidemia, there is no adequate knowledge about the most suitable in vivo model. A systematic literature search was carried out to review the animal models such as rats, mice, rabbits and zebrafish models with chemical-induced, diet-induced and drug-induced methods that have been used to study dyslipidemia. This review focuses on the mechanism involved in the dyslipidemia induction techniques explored by researchers along with their applications and limitations. The induction methods reported are expected to provide better insight in selecting an appropriate model to draw precise conclusions.
First Page
s683
Last Page
s692
DOI
10.5530/ijper.58.3s.72
Publication Date
1-1-2024
Recommended Citation
Mallya, Pooja and Lewis, Shaila A., "Selecting an Appropriate Animal Model for Dyslipidemia" (2024). Open Access archive. 10771.
https://impressions.manipal.edu/open-access-archive/10771
