Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia

Authors

Amrath Raj B K, Kasturba Hospital
Kumar Amerendra Singh, Manipal Academy of Higher Education
Hitesh Shah, Kasturba Hospital

Document Type

Article

Publication Title

Journal of Orthopaedics

Abstract

Introduction: The diagnosis of Acute lymphoblastic leukemia (ALL) is delayed due to vague presentation and normal hematological investigations. Objective: The objectives were to identify the frequency of ALL cases presented to the orthopedic department and with normal hematological investigations. Material and methods: 250 consecutive ALL cases were retrospectively evaluated to identify cases with musculoskeletal manifestations, and laboratory investigations. Results: Twenty-two patients (4- vertebral compression fractures, 12- joint pain, 6- bone pain), presented primarily to the orthopedic department. Six patients had a normal peripheral smear. Conclusion: The primary physician should maintain a high index of suspicion despite a normal peripheral smear.

First Page

326

Last Page

330

DOI

10.1016/j.jor.2020.05.022

Publication Date

11-1-2020

Recommended Citation

Raj B K, Amrath; Singh, Kumar Amerendra; and Shah, Hitesh, "Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia" (2020). Open Access archive. 1123.
https://impressions.manipal.edu/open-access-archive/1123