Systematic review and meta analysis of substance P in gingival crevicular fluid as a diagnostic biomarker for tooth pain

Document Type

Article

Publication Title

Discover Applied Sciences

Abstract

This study compiles all the in vivo studies to associate tooth pain with the levels of SP in GCF. 6 articles were included in this review. It was concluded that there is a substantial elevation of levels of SP in GCF in painful teeth compared to healthy teeth. Therefore, GCF is an excellent serum for evaluating the neuropeptide levels, but there is high heterogeneity in GCF collection and evaluation methods.

DOI

10.1007/s42452-025-07607-9

Publication Date

10-1-2025

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