A study of insulin resistance in human immunodeficiency virus patients on antiretroviral therapy and its correlation with CD4 counts, disease duration in a tertiary care centre

Document Type

Article

Publication Title

Indian Journal of Physiology and Pharmacology

Abstract

Objectives: Human immunodeficiency virus (HIV) is a major health problem with a lot of stigmas even today in developing countries that affects the immune system. Highly active antiretroviral therapy (ART) is the standard treatment for HIV and has improved the survival rate of patients. Insulin resistance (IR) is a common metabolic complication among individuals with HIV. This study was conducted to evaluate the incidence of IR among HIV patients on ART therapy and to study the correlation between CD4 counts and duration of the disease. Materials and Methods: A cross-sectional study was conducted in a hospital-based outpatient clinic among HIV-positive patients who were on ART therapy for at least 6 months. The study included 51 patients who were recruited through consecutive sampling. IR was determined using the homeostasis model assessment of IR (HOMA-IR) formula. Based on the CD4 counts, the patients were divided into three groups namely A, B and C respectively. Results: A total of 51 patients were included. Majority (39.22%) were in the age group of 41-50 years. IR is seen in 58.82% of study subjects, suggesting a common metabolic complication. IR was observed in 60% and 66.67% of participants in group B and group C, respectively. There was a weak positive correlation between CD4 counts and IR (as measured by fasting insulin and HOMA-IR). Conclusion: Results of this study suggest that IR is a common metabolic complication among individuals with HIV, with positive correlation with CD4 counts and disease duration.

First Page

248

Last Page

252

DOI

10.25259/IJPP_1_2024

Publication Date

7-1-2025

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