Sustainable Integration of Nanobiosensors in Biomedical and Civil Engineering: A Comprehensive Review

Document Type

Article

Publication Title

ACS Omega

Abstract

Nanobiosensors represent a rapidly advancing class of analytical tools, offering high sensitivity, selectivity, and real-time detection across biomedical, environmental, and structural domains. This review synthesizes foundational quantum phenomena governing sensor response at the nanoscale and explores the integration of pH-responsive polymers to enhance specificity and functional adaptability. Key methodologies in nanobiosensor design and fabrication are examined, encompassing electrochemical, optical, piezoelectric, and field-effect transistor-based systems. Emphasis is placed on diverse applications, including early disease detection, real-time structural integrity assessment, and monitoring of environmental contaminants. Technical challenges such as material stability, signal drift, and manufacturing scalability are critically analyzed alongside emerging advantages such as multiplexing, miniaturization, and low power demand. A sustainable perspective is introduced through discussions on eco-friendly materials, life cycle assessment, and green fabrication processes. By consolidating recent advancements and interdisciplinary approaches, this work provides strategic insights for the development of next-generation nanobiosensors with enhanced performance, environmental compatibility, and translational potential.

First Page

25120

Last Page

25157

DOI

10.1021/acsomega.5c00852

Publication Date

6-24-2025

This document is currently not available here.

Share

COinS