Environment signal dependent biocontainment systems for engineered organisms: Leveraging triggered responses and combinatorial systems

Document Type

Article

Publication Title

Synthetic and Systems Biotechnology

Abstract

As synthetic biology advances, the necessity for robust biocontainment strategies for genetically engineered organisms (GEOs) grows increasingly critical to mitigate biosafety risks related to their potential environmental release. This paper aims to evaluate environment signal-dependent biocontainment systems for engineered organisms, focusing specifically on leveraging triggered responses and combinatorial systems. There are different types of triggers—chemical, light, temperature, and pH—this review illustrates how these systems can be designed to respond to environmental signals, ensuring a higher safety profile. It also focuses on combinatorial biocontainment to avoid consequences of unintended GEO release into an external environment. Case studies are discussed to demonstrate the practical applications of these systems in real-world scenarios.

First Page

356

Last Page

364

DOI

10.1016/j.synbio.2024.12.005

Publication Date

6-1-2025

This document is currently not available here.

Share

COinS