Preparation of Biocompatible Antimicrobial Polymer Embedded with Ricinoleic Acid

Document Type

Article

Publication Title

Journal of Polymers and the Environment

Abstract

Global health is in jeopardy by the rising emergence of antibiotic drug resistance in pathogenic bacteria. Methicillin-resistant Staphylococcus aureus (MRSA) is a widespread bacterial infection that causes considerable morbidity and mortality on a global level. Finding promising materials for MRSA continues to prove challenging, and it is essential to quest for new and advanced polymeric therapeutics to effectively treat MRSA infections. Ricinoleic acid, a castor oil extract with an unsaturated omega-9 fatty acid and hydroxy acid has sparked growing interest because of its broad-spectrum antibacterial properties. Herein, ricinoleic acid-based polymer is synthesized to combat multidrug-resistant bacteria and few pathogenic microorganisms. The ricinoleic acid polymer (RAP) exhibited efficient antimicrobial activity against E. coli, P. aeruginosa, C. albicans, S. aureus, and MRSA with a MIC of 1.25 mg/mL, 10 mg/mL, and 0.62 mg/mL, 20 mg/mL and 10 mg/mL, respectively. Time-kill assay revealed that the polymer showed biostatic activity against all the tested pathogens. Cytotoxicity assay revealed the polymer showed 100% biocompatibility even at a higher concentration of 50 µg/mL. Effective antibacterial properties, particularly against MRSA and few pathogenic microbes, and good biocompatibility of RAP make it a promising material in surface coatings and hospital-acquired infections.

First Page

1216

Last Page

1231

DOI

10.1007/s10924-024-03459-3

Publication Date

2-1-2025

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