Evaluation of the Anaesthetic Efficacies of Three Different Formulations of Intraligamentary Injections for Hypertensive Patients with Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial

Document Type

Article

Publication Title

European Endodontic Journal

Abstract

Objective: This double-blinded randomised clinical trial aimed to compare the efficacy of lignocaine hydrochloride, diclofenac sodium, and ketorolac tromethamine as supplemental intraligamentary injections for intra-appointment pain in normotensive and hypertensive patients with moderate to severe symptomatic irreversible pulpitis. Methods: Ethical clearance was obtained, and the trial was registered on the Clinical Trial Registry India (CTRI/2020/09/027635; registered on 07/09/2020). A total of 198 patients were divided into two groups: the hypertensive group (Group HYP; n=99) and the normotensive group (Group NOR; n=99). After computerised randomisation and double blinding, participants were subdivided into three subgroups HYPLIG and NORLIG: (lignocaine hydrochloride n=33), HYPDIC and NORDIC: (diclofenac sodium n=33), and HYPKET and NORKET: (ketorolac tromethamine n=33). The preoperative visual analogue scale (VAS) scores were recorded. For the group HYP, blood pressure was recorded, and an inferior alveolar nerve block (IANB) comprising 1.8ml of 2% lignocaine hydrochloride without adrenaline was administered. For the group NOR, IANB with 1.8mL of 2% lignocaine hydrochloride with adrenaline was administered. A supplemental intraligamentary injection comprising one of the experimental drugs was injected into both groups. Endodontic access was gained, and the intraoperative VAS score was recorded. As part of the statistical analysis, paired t tests, Tukey’s post hoc test, and ANOVA were performed using SPSS software version 20. Results: Supplemental intraligamentary injections of diclofenac sodium and ketorolac tromethamine showed a statistically significant difference (p<0.05) compared to lignocaine hydrochloride in the reduction of intraoperative pain with no side effects in hypertensive and healthy individuals. Conclusion: Supplemental injections of both NSAIDs performed better than lignocaine hydrochloride in reducing intraoperative pain among healthy and hypertensive individuals.

First Page

278

Last Page

284

DOI

10.14744/eej.2024.71473

Publication Date

1-1-2025

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