An experimental study on topical application of 2% lignocaine jelly for preventing coughing and sore throat post extubation in elective surgeries in smokers vs. non-smokers

Document Type

Article

Publication Title

Biomedical and Pharmacology Journal

Abstract

Incidence of cough and sore throat post-extubation is known to be increased in cigarette smokers. Simple methods with minimal side-effects like application of 2% lignocaine jelly is observed to reduce such complications in the normal population. The rationale of this study is to directly compare such effects between smokers and non-smokers.It is an observational study including 60 participants aged between 20 to 60 years with ASA 1 and 2 physical status undergoing elective surgery under general anaesthesia. The patients were randomized in to two groups - smokers and non-smokers. Lignocaine 2% jelly was applied to endo-tracheal tube cuffs in both groups. Comparison was made between the two groups with regards to post operative cough and sore throat at intervals of 1 hour and 24 hours post extubation as well as hemodynamic variability at pre-induction, 3 mins, 15 mins post intubation and 3 mins post extubation. Students t-test, Fishers exact test and Mann-Whitney test was used for comparison between the two groups.1-hour sore throat was significantly lower in non-smoker group (p=0.000). However, incidence of 24-hour sore throat was comparable (p=0.104). The number and severity of cough was greater in smoker group, even after the application of 2% lignocaine jelly (p=0.003). There was no significant difference in hemodynamic variables pre and postoperatively.Noticeable difference was observed between smokers and non-smokers with regard to respiratory complications post-extubation. We must consider smoking as a public health hazard and effects of chronic smoking cannot be discounted when taking in to account benefits observed with lignocaine jelly on ET tube cuffs.

First Page

291

Last Page

298

DOI

10.13005/bpj/1888

Publication Date

1-1-2020

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