One-Pot Synthesis of Polyvinyl Alcohol-Piperazine Cross-Linked Polymer for Antibacterial Applications

Document Type

Article

Publication Title

Journal of Polymers and the Environment

Abstract

The spread of microbes which cause infectious diseases are of great concern on human health. Therefore, a water-soluble cross-linked polymer based on polyvinyl alcohol was synthesized via an economical, facile, and aqueous-based approach. The resultant cross-linked polymer was characterized by different techniques such as FTIR, 1H NMR, 13C NMR, TGA, and DSC. The IR spectrum has been recorded in the range 400–4000 cm−1. From thermal studies, i.e. TGA, cross-linking polymer PVA-E-Pz showed two step degradation and from DSC, glass transition temperature (Tg) was exhibited at 86.05 °C. The antimicrobial properties of the cross-linked polymer were studied using the well-diffusion technique and optical density method against gram-negative bacteria, Escherichia coli and gram-positive bacteria, Staphylococcus aureus. Polymer coated fabric was also evaluated for antimicrobial activity against both the bacteria, even after 25 wash cycles the coated fabric showed about 90% antibacterial activity. Samples showed good antimicrobial activity against both the micro-organisms, but more activity was exhibited against gram-negative bacteria. The coating durability and surface morphology of the coated fabric were also analyzed. Cytotoxicity studies revealed that PVA-E-Pz was non-toxic against human dermal fibroblast cell lines. This material might be a good fit for advanced wound dressing and textile applications. The proposed strategy provides a low-cost, environmentally friendly method for creating a new cross-linked polymer with antimicrobial activity.

First Page

4749

Last Page

4762

DOI

10.1007/s10924-022-02553-8

Publication Date

11-1-2022

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