Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation
Document Type
Article
Publication Title
EMBO Molecular Medicine
Abstract
There is an increasing need to develop biological anti-inflammatory agents that are more targeted, effective, and with lesser side effects as compared to conventional chemical drugs. In the present study, we found that Mycobacterium tuberculosis protein PPE2 and a synthetic derivative peptide can suppress the mast cell population and inhibit several vasoactive and fibrogenic mediators and pro-inflammatory cytokines induced by mast cells in formalin-induced tissue injury. PPE2 was found to inhibit transcription from the promoter of stem cell factor, important for mast cell maintenance and migration. Thus, PPE2/peptide can be used as a potent nonsteroidal therapeutic agent for the treatment of inflammation and tissue injury.
DOI
10.15252/emmm.202114891
Publication Date
9-7-2022
Recommended Citation
Pal, Ravi; Battu, Madhu Babu; and Mukhopadhyay, Sangita, "Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation" (2022). Open Access archive. 3966.
https://impressions.manipal.edu/open-access-archive/3966
