MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology

Authors

Karthik Gourishetti, University of South Carolina School of Medicine Columbia
Vignesh Balaji Easwaran, Manipal College of Pharmaceutical Sciences
Youssef Mostakim, University of South Carolina School of Medicine Columbia
K. Sreedhara Ranganath Pai, Manipal College of Pharmaceutical Sciences

Document Type

Article

Publication Title

Biology

Abstract

MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

DOI

10.3390/biology12070922

Publication Date

7-1-2023

Recommended Citation

Gourishetti, Karthik; Balaji Easwaran, Vignesh; Mostakim, Youssef; and Ranganath Pai, K. Sreedhara, "MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology" (2023). Open Access archive. 5471.
https://impressions.manipal.edu/open-access-archive/5471