Safety Profile of Monoclonal Antibodies and Subsequent Drug Developments in the Treatment of Paroxysmal Nocturnal Hemoglobinuria
Document Type
Article
Publication Title
Medicina (Lithuania)
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease characterized by intravascular hemolysis due to the targeting of affected red blood cells by the complement system. Eculizumab and ravulizumab are two monoclonal antibodies that inhibit the complement system’s components and have been shown to significantly improve survival and quality of life. This review describes the role of these monoclonal antibodies in the treatment of PNH with an emphasis on their safety profile. The challenges in the use of these drugs and new drugs in various stages of drug development are also described, which may be helpful in addressing some of these challenges.
DOI
10.3390/medicina60030379
Publication Date
3-1-2024
Recommended Citation
Mallenahalli Neeekantappa, Vasantha; Kamath, Ashwin; and Bharathi Rajaduraivelpandian, Poovizhi, "Safety Profile of Monoclonal Antibodies and Subsequent Drug Developments in the Treatment of Paroxysmal Nocturnal Hemoglobinuria" (2024). Open Access archive. 6755.
https://impressions.manipal.edu/open-access-archive/6755
