Green multicomponent synthesis of pyrano[2,3-c]pyrazole derivatives: current insights and future directions

Document Type

Article

Publication Title

RSC Advances

Abstract

The past decade has witnessed significant progress in synthesizing structurally diverse and biologically relevant pyrano[2,3-c]pyrazole derivatives through the integration of green methodologies. This review summarizes the recent advances in the green multicomponent synthesis of pyrano[2,3-c]pyrazole and spiro-pyrano[2,3-c]pyrazole derivatives. These include the application of energy-efficient techniques such as microwave and ultrasound-assisted synthesis, benign catalysts and biodegradable composites, solvent selection with a focus on water as a renewable and non-toxic medium, and solvent-free conditions. The review consolidates the current knowledge and future research directions, providing a valuable resource for researchers dedicated to advancing green chemistry practices.

First Page

28798

Last Page

28833

DOI

10.1039/d3ra05570a

Publication Date

10-2-2023

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