Norovirus Infection in Children with Acute Lymphoblastic Leukemia

Document Type

Article

Publication Title

Infection and Chemotherapy

Abstract

Norovirus infection in children on treatment for acute lymphoblastic leukemia can lead to severe morbidity due to chronic viral shedding, malabsorption, failure to thrive, and interruption of chemotherapy. We had four children with norovirus diarrhoea in eight years period in our pediatric oncology unit. Three children under two years of age had chronic noroviral shedding and persistent diarrhoea, probably due to poor adaptive immune responses. Two of those children didn’t respond to nitazoxanide and succumbed to the illness. The third patient who received nitazoxanide and favipiravir, is currently well on chemotherapy.

First Page

403

Last Page

407

DOI

10.3947/ic.2023.0058

Publication Date

9-1-2023

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