Mathematical Models to Compare the Pharmacokinetics of Methadone, Buprenorphine, Tramadol, and Tapentadol †

Document Type

Article

Publication Title

Engineering Proceedings

Abstract

The study of a drug’s absorption, distribution, metabolization, and excretion by the body is known as pharmacokinetics (PK). In pharmacokinetics, the two-compartment model is used to understand the distribution and elimination of drugs. The two-compartment model represents the body as two distinct compartments: the central compartment (such as the blood) and the peripheral compartment (such as tissues). This work aims to enhance the understanding of drug kinetics inside the human body by comparing different mathematical models. The important focus of this study is to compare the distribution patterns of the drugs methadone, buprenorphine, tramadol, and tapentadol when administered intravenously using a two-compartment model. To mathematically describe the distribution of drugs in the body, a system of nonlinear ordinary differential equations is employed. These equations capture the dynamics of drug concentration in the different compartments over time. The roots are obtained by solving this system of equations using numeric analysis techniques. The study determines the duration of the drugs to attain the minimum effective concentration in the blood by analyzing the obtained results. Furthermore, the study also determines the time it takes for these drugs to be eliminated from the body. This data is significant for understanding the drug’s clearance rate and its potential duration of action. By comparing the distribution patterns and elimination rates of methadone, buprenorphine, tramadol, and tapentadol, the study provides insights into the differences between these drugs in terms of their pharmacokinetic properties. Healthcare professionals can utilize this information to optimize drug therapy, ensuring that the drugs are administered in accurate amounts and at precise intervals to target the desired therapeutic effect. Overall, this study provides a comprehensive analysis of drug kinetics, aiding in a better understanding of drug behavior within the human body and facilitating informed decision making in clinical settings.

DOI

10.3390/engproc2023059055

Publication Date

1-1-2023

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