Summary of - Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study

Document Type

Article

Abstract

Key Findings

  • Probiotics significantly reduced radiation-induced damage to intestinal villi and mucosal thickness.
  • Bacterial supplementation decreased pyknotic cell numbers and neuronal inflammation in brain regions affected by radiation exposure.
  • Probiotic supplementation reduced radiation-induced villi and crypt damage, retained intestinal integrity, and reduced neuroinflammation.
  • Probiotics have shown potential in enhancing neurogenesis, recovering memory deficits, and reducing oxidative stress in the brain.

Objectives

The study aimed to evaluate the radioprotective effect of probiotics on intestinal and brain tissue after whole-body irradiation in mice.

Methods

  • Male C57BL/6 mice were divided into control, radiation, probiotics, and probiotics + radiation groups.
  • Mice were administered oral probiotics and irradiated with a single dose of whole-body radiation to assess the impact on intestinal and neuronal damage.
  • Histological analysis of intestine and brain tissues was conducted post-treatment.

Results

  • Probiotics mitigated radiation-induced damage to intestinal villi and mucosal thickness.
  • Bacterial supplementation reduced pyknotic cell numbers and neuronal inflammation in brain regions affected by radiation.
  • Probiotic supplementation reduced radiation-induced intestinal and neuronal damage, retained intestinal integrity, and reduced neuroinflammation.
  • Probiotics showed potential in enhancing neurogenesis, recovering memory deficits, and reducing oxidative stress in the brain.

Conclusions

  • Probiotics could attenuate radiation-induced intestinal and neuronal damage, suggesting a potential protective role against radiation toxicity.

Recommended Citation

Venkidesh BS, Shankar SR, Narasimhamurthy RK, Rao SBS, Mumbrekar KD. Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study. Clin Transl Oncol. 2023 Nov;25(11):3165-3173. DOI: 10.1007/s12094-023-03184-8

Publication Date

2023

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