Summary of - lamotrigine—a review of analytical methods developed for pharmaceutical formulations and biological matrices
Document Type
Article
Abstract
Lamotrigine owing to its excellent inhibitory property of neurotransmitter release especially glutamate is used in the treatment of epilepsy as a second-line antiepileptic drug. It differs from other antiepileptic drugs chemically and pharmacologically and is used as both monotherapy and adjunct therapy in the treatment of epilepsy. The present review focuses on two aspects (a) various analytical methods used in quantification of Lamotrigine in pharmaceutical formulations and (b) various analytical methods used to determine Lamotrigine in biological matrices. Here the various analytical methods are developed using different parameters and validation of employed methods is discussed. Estimated parameters like the linearity, LOD (Limit of detection) and LOQ (Limit of quantification) of validation are discussed for the individual method. The critical quality attributes like the wavelength of detection, mobile phase, columns, flow rate, retention time, and the sample preparation methods for the estimation of Lamotrigine by bioanalytical methods are also discussed.
S, S., Kumar, L., & Verma, R. (2021). Lamotrigine—A Review of Analytical Methods Developed for Pharmaceutical Formulations and Biological Matrices. Critical Reviews in Analytical Chemistry, 52(7), 1451–1460. https://doi.org/10.1080/10408347.2021.1886901
Publication Date
2022
Recommended Citation
S, Sajeeda; Kumar, Lalit; and Verma, Ruchi, "Summary of - lamotrigine—a review of analytical methods developed for pharmaceutical formulations and biological matrices" (2022). Open Access archive. 9192.
https://impressions.manipal.edu/open-access-archive/9192
