Summary of - Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms
Document Type
Article
Abstract
Summary
Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs can also have genotoxic effects on humans who are exposed to them. This review summarizes the research on DNA damage caused by OPs, the mechanisms behind this damage, and the resulting cellular effects.
Acute and chronic exposure to OPs can induce genotoxicity by altering the normal structure of DNA and induce cell death among exposed individuals, such as farmers, the general population, and industrial employees. The studies that were reviewed here demonstrate that OPs induce genotoxicity, both in vitro and in vivo, and the mechanism of OP toxicity can have harmful effects on human health and cause multiple types of disorders. These findings also indicate that pesticide toxicity is linked with oxidative stress regardless of the target tissue. However, the type and exposure duration following pesticide exposure in many studies limits our ability to draw definitive comparisons between the genotoxic potential of each OP in different model systems, which may need to be further evaluated. Further investigation of the types of DNA damage caused by different OPs and their relative significance in repair efficiency could provide important insight into their genotoxicity. Understanding the types of DNA damage induced by OPs and their mechanisms would help to evaluate the risk to humans following toxic exposure and prevent the lethal consequences of OPs by limiting pesticide use and developing novel approaches for therapeutic interventions.
Recommended Citation
Prathiksha, J., Narasimhamurthy, R.K., Dsouza, H.S. et al. Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms. Mol Biol Rep 50, 5465–5479 (2023). https://doi.org/10.1007/s11033-023-08424-2
Publication Date
2023
Recommended Citation
Prathiksha, Joyline; Narasimhamurthy, Rekha K; Sunil Dsouza, Herman; and Mumbrekar, Kamalesh D, "Summary of - Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms" (2023). Open Access archive. 9200.
https://impressions.manipal.edu/open-access-archive/9200
