Summary of - Theta and gamma oscillatory dynamics in mouse models of Alzheimer’s disease: A path to prospective therapeutic intervention

Document Type

Article

Abstract

Study Background: This review presented titled “theta and gamma oscillatory dynamics in mouse models of alzheimer's disease: a path to prospective therapeutic intervention” by Sonam Fathima Mehak, Apoorva Bettagere Shivakumar, Sparsha Kumari, Bhadra Muralidharan, Gireesh Gangadharan is on the role of brain oscillations, especially theta and gamma rhythms on behavioral alterations asscociated with Alzheimer's disease. Understanding the neural basis of cognitive deficits, a key feature of Alzheimer’s disease (AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in neural systems are a fundamental mechanism for diverse brain functions, including cognition. In several neurological conditions like AD, aberrant neural oscillations have been shown to play a central role. Furthermore, manipulation of brain oscillations in animals has confirmed their impact on cognition and disease. In this article, we review the evidence from mouse models that shows how synchronized oscillatory activity is intricately linked to AD machinery. We primarily focus on recent reports showing abnormal oscillatory activities at theta and gamma frequencies in AD condition and their influence on cellular disturbances and cognitive impairments. A thorough comprehension of the role that neuronal oscillations play in AD pathology should pave the way to therapeutic interventions that can curb the disease.

Publication Date

2022

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