Summary of - Evaluation of Nephroprotective Effect of Vortioxetine in Gentamicin-Induced Renotoxicity in Wistar rats
Document Type
Article
Abstract
Introduction- Gentamicin, an aminoglycoside, is a commonly prescribed antibiotic in cases of severe infections caused by gram-negative bacteria. Though being a very effective drug against gram negative organisms, its potential to cause nephrotoxicity restricts its use. The study aimed to evaluate the nephro-protective effect of vortioxetine in gentamicin-induced renotoxicity in wistar rats.
Method- Twenty-four female wistar albino rats weighing 180-220g, 8-10-week old were selected for the study and randomly assigned to 4 groups. Group 1: normal control, received only distilled water; Group 2: gentamicin 80mg/kg b.w. for 8 days; Group 3: vortioxetine 10mg/kg b.w., pre-treatment for 5 days followed by gentamicin 80mg/kg b.w. for 8 days; Group 4: vortioxetine 20mg/kg b.w., pre-treatment for 5 days followed by gentamicin 80mg/kg b.w. for 8 days. At the end of the experiment, serum urea, serum creatinine, tissue malondialdehyde (MDA) and tissue glutathione (GSH) were estimated and histological examination of kidneys was performed. Statistical analysis was done using One-way ANOVA and post hoc Tukey’s test.
Results- Serum urea, serum creatinine and tissue MDA were markedly increased while tissue GSH significantly reduced in group 2 compared to other groups (p<0.001). Treatment with vortioxetine in group 3 and 4, reduced serum urea, serum creatinine, and MDA levels, and elevated GSH levels compared to group 2 (p< 0.001). This was supported by histopathological evidence.
Conclusion- Vortioxetine has shown a protective effect on gentamicin-induced nephrotoxicity in rats.
Citation to the base paper: Meghana Bhat M, Bhat VR, Parida A, Sushma RK, Poojar B, Manju V. Evaluation of Nephroprotective Effect of Vortioxetine in Gentamicin-Induced Renotoxicity in Wistar rats. Research Journal of Pharmacy and Technology. 2023 May;16(5):2223-8.
Publication Date - 2023
Publication Date
2023
Recommended Citation
Bhat M, Meghana; Bhat, Vinutha R; Parida, Amrita; R K, Sushma; Poojar, Basavaraj; and V, Manju, "Summary of - Evaluation of Nephroprotective Effect of Vortioxetine in Gentamicin-Induced Renotoxicity in Wistar rats" (2023). Open Access archive. 9290.
https://impressions.manipal.edu/open-access-archive/9290
