Summary of - An intriguing case of cutaneous noduloulcerative lesion in the vicinity of genitalia

Document Type

Article

Abstract

A 41‑year‑old married man presented with an asymptomatic ulcerated mass over the right inner aspect of the thigh for 3 weeks. Cutaneous examination revealed well‑circumscribed, ulcerated plaque with few satellites such as erythematous and infiltrated nodules. There was stony hard induration of the underlying and surrounding skin with a local rise of temperature. Bilateral inguinal, left cervical and submandibular lymph nodes were enlarged and nontender. Histopathological examination revealed a dermal diffuse infiltrate with sheets of small‑to‑intermediate abnormal lymphoid cells with focal epidermotropism. Immunohistochemistry of tumor cells was positive for CD30 (strong and equal intensity staining at the cell membrane and Golgi region), LCA, and MUM‑1 and negative for CK, CD3, CD5, CD20, CD138, PAX‑5, ALK, and EMA. Ki67 index was >80%. Fluorodeoxyglucose positron emission tomography scan revealed multiple liver, lung spleen, and bone metastases. A diagnosis of Stage IV metastatic Non‑Hodgkin’s lymphoma; anaplastic large cell lymphoma (ALCL)‑anaplastic lymphoma kinase (ALK)‑negative subtype was made.

Publication Date

2023

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