Summary of - Reversible myelofibrosis secondary to systemic lupus erythematosus

Document Type

Article

Abstract

It is case of a woman in her late 40s who presented to us with bleeding manifestations of petechial rash and menorrhagia, which on further evaluation showed pancytopenia. Bone marrow examination revealed myelofibrosis. Further evaluation led to the diagnosis of SLE. Treatment of SLE with immunosuppression resulted in resolution of myelofibrosis on repeat marrow examination and significant clinical improvement. Pancytopenia due to bone marrow fibrosis secondary to SLE is an extremely rare entity. Primary presentation of SLE with bleeding manifestation is also a rare phenomenon with only 20 cases reported so far in world literature. Partial to complete regression of myelofibrosis is noted following treatment in secondary myelofibrosis caused by SLE. Our case underlines multiple features like primary bleeding manifestation and regression of myelofibrosis following treatment which is rarely reported in association with SLE.

Publication Date

August 17, 2023.

Recommended Citation

Rama Krishna Reddy MM, Boloor A, Thomas NK Reversible myelofibrosis secondary to systemic lupus erythematosus BMJ Case Reports CP 2023;16:e255229.

https://doi.org/10.1136/bcr-2023-255229

Publication Date

2023

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